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Chemical Structure : ORM-10962
Catalog No.: PC-63232Not For Human Use, Lab Use Only.
ORM-10962 is a potent, highly selective sodium-calcium exchanger (NCX) inhibitor, significantly reduces inward/outward NCX currents with IC50 of 55 and 67 nM, respectively.
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ORM-10962 is a potent, highly selective sodium-calcium exchanger (NCX) inhibitor, significantly reduces inward/outward NCX currents with IC50 of 55 and 67 nM, respectively。
ORM-10962 does not modify significantly the magnitude of ICaL in cardiac myocytes, as well as the inward rectifier, transient outward, IKs, the late and peak sodium and Na+/K+ pump currents。
ORM-10962 can exert positive as well as negative inotropic effect depending on the actual operation mode of NCX.
| M.Wt | 459.546 | |
| Formula | C27H29N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kohajda Z, et al. PLoS One. 2016 Nov 10;11(11):e0166041.
2. Oravecz K, et al. Eur J Pharmacol. 2018 Jan 5;818:278-286.
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