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You are here:Home-Chemical Inhibitors & Agonists-Nuclear Receptor/Transcription Factor-Androgen Receptor (AR)-ORM-15341
ORM-15341

Chemical Structure : ORM-15341

CAS No.: 1297537-33-7

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ORM-15341 (Ketodarolutamide, BAY1896953, ORM15341)

Catalog No.: PC-45612Not For Human Use, Lab Use Only.

ORM-15341 (Ketodarolutamide, BAY1896953) is the active main metabolite of ODM-201, a potent wt/mutant androgen receptor (AR) inhibitor, inhibits wtAR/AR(F876L) with IC50s of 25/51 nM respectively.

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25 mg $158 In stock
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100 mg $398 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ORM-15341 (Ketodarolutamide, BAY1896953) is the active main metabolite of ODM-201, a potent wt/mutant androgen receptor (AR) inhibitor, inhibits wtAR/AR(F876L) with IC50s of 25/51 nM respectively.
ORM-15341 (Ketodarolutamide, BAY1896953) suppresses androgen-induced cell proliferation more efficaciously than enzalutamide or ARN-509.

Physicochemical Properties

M.Wt 396.8303
Formula C19H17ClN6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 37 mg/mL
Chemical Name/SMILES

1H-Pyrazole-3-carboxamide, 5-acetyl-N-[(1S)-2-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-

References

1. Moilanen AM, et al. Sci Rep. 2015 Jul 3;5:12007.

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