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OSI-296

Chemical Structure : OSI-296

CAS No.: 1175296-94-2

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OSI-296 (OSI 296)

Catalog No.: PC-49517Not For Human Use, Lab Use Only.

OSI-296 is a potent and selective inhibitor of c-MET and RON kinases with cellular IC50 of 42 and 200 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    OSI-296 is a potent and selective inhibitor of c-MET and RON kinases with cellular IC50 of 42 and 200 nM, respectively.
    OSI-296 shows in vivo efficacy in tumor xenografts models upon oral dosing and is well tolerated.

    Physicochemical Properties

    M.Wt 465.31
    Formula C21H19Cl2FN4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-4-(6-amino-7-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)furo[3,2-c]pyridin-3-yl)-3,6-dihydropyridine-1(2H)-carboxamide

    References

    1. Arno G Steinig, et al. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4381-7.

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