Chemical Structure : OSI-420
CAS No.:
183320-51-6
OSI-420
(Desmethyl Erlotinib;CP-473420;OSI420;OSI 420;CP473420;CP 473420)
Catalog No. : PC-43436Not For Human Use, Lab Use Only.
OSI-420 (Desmethyl Erlotinib, CP-473420) is an active metabolite of erlotinib, which is a potent EGFR tyrosin kinase inhibitor for treatment of NSCLC..
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4343601
Biological Activity
OSI-420 (Desmethyl Erlotinib, CP-473420) is an active metabolite of erlotinib, which is a potent EGFR tyrosin kinase inhibitor for treatment of NSCLC.
Physicochemical Properties
M.Wt
415.87
Formula
C21H22ClN3O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 4.2 mg/mL
Chemical Name/SMILES
Ethanol, 2-[[4-[(3-ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]-, hydrochloride (1:1)
References
1. Broniscer A, et al. Clin Cancer Res. 2007 Mar 1;13(5):1511-5.
2. Meany HJ, et al. Cancer Chemother Pharmacol. 2008 Aug;62(3):387-92.
3. Togashi Y, et al. J Thorac Oncol. 2010 May;5(5):601-5.
4. Flaig TW, et al. Br J Cancer. 2010 Sep 7;103(6):796-801.
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