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OSU-T315

Chemical Structure : OSU-T315

CAS No.: 1333146-24-9

OSU-T315 (OSU-T 315)

Catalog No.: PC-45519Not For Human Use, Lab Use Only.

OSU-T315 is a potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

OSU-T315 is a potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 uM.
OSU-T315 exhibits high in vitro potency against a panel of prostate and breast cancer cell lines (IC50=1-2.5 uM) with no effect on normal epithelial cells.
OSU-T315 facilitates the dephosphorylation of Akt at Ser-473 and other ILK targets, including GSK-3β and myosin light chain.
OSU-T315 suppresses the expression of the transcription/translation factor YB-1 and HER2, EGFR in PC-3 cells, induces autophagy and apoptosis.
OSU-T315 demonstrates in vivo efficacy in suppressing PC-3 xenograft tumor growth; orally active.

Physicochemical Properties

M.Wt 533.5873
Formula C30H30F3N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1H-Pyrazole-3-propanamide, N-methyl-1-[4-(1-piperazinyl)phenyl]-5-[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-

References

1. Lee SL, et al. J Med Chem. 2011 Sep 22;54(18):6364-74.

2. Liu TM, et al. Blood. 2015 Jan 8;125(2):284-95.

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