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Chemical Structure : OSU-T315
CAS No.: 1333146-24-9
Catalog No.: PC-45519Not For Human Use, Lab Use Only.
OSU-T315 is a potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $488 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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OSU-T315 is a potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 uM.
OSU-T315 exhibits high in vitro potency against a panel of prostate and breast cancer cell lines (IC50=1-2.5 uM) with no effect on normal epithelial cells.
OSU-T315 facilitates the dephosphorylation of Akt at Ser-473 and other ILK targets, including GSK-3β and myosin light chain.
OSU-T315 suppresses the expression of the transcription/translation factor YB-1 and HER2, EGFR in PC-3 cells, induces autophagy and apoptosis.
OSU-T315 demonstrates in vivo efficacy in suppressing PC-3 xenograft tumor growth; orally active.
| M.Wt | 533.5873 | |
| Formula | C30H30F3N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Pyrazole-3-propanamide, N-methyl-1-[4-(1-piperazinyl)phenyl]-5-[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]- |
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1. Lee SL, et al. J Med Chem. 2011 Sep 22;54(18):6364-74.
2. Liu TM, et al. Blood. 2015 Jan 8;125(2):284-95.
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