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Chemical Structure : OTB-658
Catalog No.: PC-20081Not For Human Use, Lab Use Only.
OTB-658 (OTB658) is a novel oxazolidinone anti-tuberculosis agent, shows potent antibacterial activity against Mycobacterium tuberculosis, especially multi-drug resistant tuberculosis (MDR-TB) in vitro and in vivo.
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OTB-658 (OTB658) is a novel oxazolidinone anti-tuberculosis agent, shows potent antibacterial activity against Mycobacterium tuberculosis, especially multi-drug resistant tuberculosis (MDR-TB) in vitro and in vivo.
OTB-658 exhibits potent activity against M. tuberculosis H37Rv in the early stage of infection.
OTB-658 has MIC value of 0.080 to 0.115 μg/ml against M. tuberculosis H37Rv.
OTB-658 is active against 10 drug-susceptible and 30 drug-resistant clinical isolates and is as potent as Linezolid and PNU-100480 (Sutezolid).
OTB-658 achieves bacteriostatic effect against M. tuberculosis at the MIC to 32× MIC (MBC).
OTB-658 (25 mg/kg) demonstrates better bacteriostatic activity in the early stage of infection in acute murine models, compared with Linezolid (50 mg/kg). OTB-658 shows no cross-resistance with Isoniazid (INH) and Rifampin (RIF).
| M.Wt | 381.42 | |
| Formula | C17H20FN3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Guo S, et al. Antimicrob Agents Chemother. 2021 Oct 18;65(11):e0097421.
2. Liu H, et al. Antimicrob Agents Chemother. 2023 Feb 16;67(2):e0139922.
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