OTX008 | Galectin-1 inhibitor | Probechem Biochemicals

Chemical Structure : OTX008

CAS No.: 286936-40-1

OTX008 (Calixarene 0118, PTX-008)

Catalog No.: PC-61646Not For Human Use, Lab Use Only.

OTX008 (Calixarene 0118, PTX-008) is a is a calixarene derivative designed to bind the Galectin-1 (Gal1) amphipathic β-sheet conformation.

Packing	Price	Stock
5 mg	$158	In stock
10 mg	$248	In stock
25 mg	$438	In stock
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Biological Activity

OTX008 (Calixarene 0118, PTX-008) is a calixarene derivative designed to bind the Galectin-1 (Gal1) amphipathic β-sheet conformation.
OTX008 inhibits Gal1 expression and ERK1/2 and AKT-dependent survival pathways, and induces G2/M cell cycle arrest through CDK1.
OTX008 inhibits proliferation and invasion at micromolar concentrations in cancer cells.
OTX008 inhibits growth of A2780-1A9 xenografts in vivo.

Physicochemical Properties

M.Wt	937.18
Formula	C52H72N8O8
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Acetamide, 2,2',2'',2'''-[(2-methylpentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3,5,7(28),9,11,13(27),15,17,19(26),21,23-dodecaene-25,26,27,28-tetrayl)tetrakis(oxy)]tetrakis[N-[2-(dimethylamino)ethyl]-

References

1. Dings RP, et al. J Med Chem. 2012 Jun 14;55(11):5121-9.

2. Astorgues-Xerri L, et al. Eur J Cancer. 2014 Sep;50(14):2463-77.

3. Dings RP, et al. Cancer Lett. 2008 Jul 8;265(2):270-80.

4. Zucchetti M, et al. Cancer Chemother Pharmacol. 2013 Oct;72(4):879-87.

OTX008 (Calixarene 0118, PTX-008)

Biological Activity

Physicochemical Properties

References

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