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Chemical Structure : OTX008
CAS No.: 286936-40-1
Catalog No.: PC-61646Not For Human Use, Lab Use Only.
OTX008 (Calixarene 0118, PTX-008) is a is a calixarene derivative designed to bind the Galectin-1 (Gal1) amphipathic β-sheet conformation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $438 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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OTX008 (Calixarene 0118, PTX-008) is a calixarene derivative designed to bind the Galectin-1 (Gal1) amphipathic β-sheet conformation.
OTX008 inhibits Gal1 expression and ERK1/2 and AKT-dependent survival pathways, and induces G2/M cell cycle arrest through CDK1.
OTX008 inhibits proliferation and invasion at micromolar concentrations in cancer cells.
OTX008 inhibits growth of A2780-1A9 xenografts in vivo.
| M.Wt | 937.18 | |
| Formula | C52H72N8O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Acetamide, 2,2',2'',2'''-[(2-methylpentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3,5,7(28),9,11,13(27),15,17,19(26),21,23-dodecaene-25,26,27,28-tetrayl)tetrakis(oxy)]tetrakis[N-[2-(dimethylamino)ethyl]- |
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1. Dings RP, et al. J Med Chem. 2012 Jun 14;55(11):5121-9.
2. Astorgues-Xerri L, et al. Eur J Cancer. 2014 Sep;50(14):2463-77.
3. Dings RP, et al. Cancer Lett. 2008 Jul 8;265(2):270-80.
4. Zucchetti M, et al. Cancer Chemother Pharmacol. 2013 Oct;72(4):879-87.
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