OUL312 | PARP10 inhibitor | Probechem Biochemicals

Chemical Structure : OUL312

OUL312 (OUL-312)

Catalog No.: PC-25415Not For Human Use, Lab Use Only.

OUL312 (OUL-312) is a potent, selective PARP10 inhibitor with IC50 of 20 nM, 75-fold selectivity over PARP15 (IC50=1500 nM).

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Biological Activity

OUL312 (OUL-312) is a potent, selective PARP10 inhibitor with IC50 of 20 nM, 75-fold selectivity over PARP15 (IC50=1500 nM).
OUL312 displays 18-fold selectivity over PARP11 (IC50=360 nM), little to no activity against all the poly-ARTs enzymes as well as for PARP3 and PARP4.
OUL312 rescues cells from PARP10-induced apoptosis with EC50 of <1 uM.

Physicochemical Properties

M.Wt	300.29
Formula	C16H13FN2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-[2-(2-fluorophenyl)ethoxy]-1,2,3,4-tetrahydrophthalazine-1,4-dione

References

1. Alaviuhkola J, et al. Eur J Med Chem. 2025 Sep 1;300:118111.

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OUL312 (OUL-312)

Biological Activity

Physicochemical Properties

References

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