OUN20985 | CRBN degrader | Probechem Biochemicals

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Chemical Structure : OUN20985

CAS No.: 2244520-98-5

OUN20985 (Homo-PROTAC cereblon degrader 1)

Catalog No.: PC-25737Not For Human Use, Lab Use Only.

Homo-PROTAC cereblon degrader 1 (OUN20985) is a potent and efficient cereblon (CRBN) degrader with minimal effects on IKZF1 and IKZF3, induces ubiquitination and proteasomal degradation of CRBN.

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10 mg	$528	In stock
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Biological Activity

Homo-PROTAC cereblon degrader 1 (OUN20985) is a potent and efficient cereblon (CRBN) degrader with minimal effects on IKZF1 and IKZF3, induces ubiquitination and proteasomal degradation of CRBN.

Physicochemical Properties

M.Wt	660.64
Formula	C32H32N6O10
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4,4'-(((Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(azanediyl))bis(2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione)

References

1. Steinebach C, et al. Homo-PROTACs for the Chemical Knockdown of Cereblon. ACS Chem Biol. 2018 Sep 21;13(9):2771-2782.

2. Langousis G, et al. Nat Commun. 2025 Nov 19;16(1):10157.

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OUN20985 (Homo-PROTAC cereblon degrader 1)

Biological Activity

Physicochemical Properties

References

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