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You are here:Home-Chemical Inhibitors & Agonists-Cytoskeleton/Cell Adhesion Molecules-Microtubule/Tubulin-OXi6196
OXi6196

Chemical Structure : OXi6196

CAS No.: 360796-40-3

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OXi6196 (Oxi-6196)

Catalog No.: PC-25512Not For Human Use, Lab Use Only.

OXi6196 is a potent tubulin-binding agent with IC50 of 200 nM for inhibition of tubulin polymerization utilizing a cell-free assay.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

OXi6196 is a potent tubulin-binding agent with IC50 of 200 nM for inhibition of tubulin polymerization utilizing a cell-free assay.
OXi6196 shows cytotoxicity in the low nM range (IC50 2.2–4.5 nM) in human SK-OV-3 ovarian, DU-145 prostate, NCI-H460 lung cells and murine hemangioendothelioma MHEC-5T cancer cells.
OXi6196 caused G2/M cell cycle arrest.
OXi6196 (100 nM) disrupted capillary-like endothelial networks pre-established with HUVECs on Matrigel®.

Physicochemical Properties

M.Wt 342.39
Formula C20H22O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-methoxy-5-(3,4,5-trimethoxyphenyl)-7,8-dihydronaphthalen-1-ol

References

1. Liu L, et al. Cancers (Basel). 2022 Aug 30;14(17):4208.

2. Maguire C.J, et al. Medchemcomm. 2018;9:1649–1662.

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