Chemical Structure : OXi6197
CAS No.:
666712-68-1
OXi6197
(KGP04)
Catalog No.: PC-25513Not For Human Use, Lab Use Only.
OXi6197 (KGP04) is the phosphate prodrug of OXi6196, which is a potent tubulin-binding agent with IC50 of 200 nM for inhibition of tubulin polymerization, rapidly releases OXi6196 in the presence of alkaline phosphatase.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
OXi6197 (KGP04) is the phosphate prodrug of OXi6196, which is a potent tubulin-binding agent with IC50 of 200 nM for inhibition of tubulin polymerization, rapidly releases OXi6196 in the presence of alkaline phosphatase.
OXi6197 (25 to 100 mg/kg daily for 5 days, i.p.) significantly inhibited growth of MDA-MB-231 in mice.
OXi6197causees vascular disruption and tumor growth delay in vivo based on orthotopic human MDA-MB-231 human breast tumor xenografts in NOD SCID mice and orthotopic RENCA kidney tumors in syngeneic BALB/C mice.
Physicochemical Properties
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M.Wt
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466.33
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Formula
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C20H21Na2O8P
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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sodium 2-methoxy-5-(3,4,5-trimethoxyphenyl)-7,8-dihydronaphthalen-1-yl phosphate
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References
1. Liu L, et al. Cancers (Basel). 2022 Aug 30;14(17):4208.
2. Maguire C.J, et al. Medchemcomm. 2018;9:1649–1662.
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