OXi8006 | Tubulin inhibitor | Probechem Biochemicals

Chemical Structure : OXi8006

OXi8006 (Oxi-8006)

Catalog No.: PC-23630Not For Human Use, Lab Use Only.

OXi8006 is a small molecule vascular disrupting agent and tubulin binding inhibior, inhibits tubulin assembly (IC50=1.1 uM) and shows cytotoxicity with GI50 of 3.45 nM against SK-OV-3 cells.

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Biological Activity

OXi8006 is a small molecule vascular disrupting agent and tubulin binding inhibior, inhibits tubulin assembly (IC50=1.1 uM) and shows cytotoxicity with GI50 of 3.45 nM against SK-OV-3 cells.

Physicochemical Properties

M.Wt	463.49
Formula	C26H25NO7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-(3-hydroxy-4-methoxyphenyl)-6-methoxy-1H-indol-3-yl)(3,4,5-trimethoxyphenyl)methanone

References

1. Strecker TE, et al. Cancer Lett. 2015 Dec 1;369(1):229-41.

2. Macdonough MT, et al. Bioorg Med Chem. 2013 Nov 1;21(21):6831-43.

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OXi8006 (Oxi-8006)

Biological Activity

Physicochemical Properties

References

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