OXi8007

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Chemical Structure : OXi8007

Catalog No.: PC-25515Not For Human Use, Lab Use Only.

OXi8007 is a vascular disrupting agent and watersoluble phosphate prodrug of OXi8006, inhibits tubulin assembly with IC50 of 1.1 uM, shows cytotoxic against DU-145 cells with GI50 of 36 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

OXi8007 is a vascular disrupting agent and watersoluble phosphate prodrug of OXi8006, inhibits tubulin assembly with IC50 of 1.1 uM, shows cytotoxic against DU-145 cells with GI50 of 36 nM.

Physicochemical Properties

M.Wt	587.43
Formula	C26H24NNa2O10P
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methanone, [6-methoxy-2-[4-methoxy-3-(phosphonooxy)phenyl]-1H-indol-3-yl](3,4,5-trimethoxyphenyl)-, sodium salt (1:2)

References

1. Hadimani MB, et al. J Nat Prod. 2013 Sep 27;76(9):1668-78.

2. Strecker TE, et al. Cancer Lett. 2015 Dec 1;369(1):229-41.

3. Dalal S, et al. Eur J Cancer. 2009 Mar;45(4):713-22.

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OXi8007

Biological Activity

Physicochemical Properties

References

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