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OXi8007

Chemical Structure : OXi8007

CAS No.: 288847-41-6

OXi8007

Catalog No.: PC-25515Not For Human Use, Lab Use Only.

OXi8007 is a vascular disrupting agent and watersoluble phosphate prodrug of OXi8006, inhibits tubulin assembly with IC50 of 1.1 uM, shows cytotoxic against DU-145 cells with GI50 of 36 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

OXi8007 is a vascular disrupting agent and watersoluble phosphate prodrug of OXi8006, inhibits tubulin assembly with IC50 of 1.1 uM, shows cytotoxic against DU-145 cells with GI50 of 36 nM.

Physicochemical Properties

M.Wt 587.43
Formula C26H24NNa2O10P
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Methanone, [6-methoxy-2-[4-methoxy-3-(phosphonooxy)phenyl]-1H-indol-3-yl](3,4,5-trimethoxyphenyl)-, sodium salt (1:2)

References

1. Hadimani MB, et al. J Nat Prod. 2013 Sep 27;76(9):1668-78.

2. Strecker TE, et al. Cancer Lett. 2015 Dec 1;369(1):229-41.

3. Dalal S, et al. Eur J Cancer. 2009 Mar;45(4):713-22.

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