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Obafluorin

Chemical Structure : Obafluorin

CAS No.: 92121-68-1

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Obafluorin

Catalog No.: PC-27987Not For Human Use, Lab Use Only.

Obafluorin is a beta-lactone antibiotic with activity against both Gram-positive and -negative pathogens, inhibits E. coli and P. fluorescens threonyl-tRNA synthetase (ThrRS, TRS) with IC50 of 35 nM and 4.3 nM respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Obafluorin is a beta-lactone antibiotic with activity against both Gram-positive and -negative pathogens, inhibits E. coli and P. fluorescens threonyl-tRNA synthetase (ThrRS, TRS) with IC50 of 35 nM and 4.3 nM respectively.

Physicochemical Properties

M.Wt 358.31
Formula C17H14N2O7
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,3-Dihydroxy-N-((2R,3S)-2-(4-nitrobenzyl)-4-oxooxetan-3-yl)benzamide

References

1. Wells JS, et al. J Antibiot (Tokyo). 1984 Jul;37(7):802-3.

2. Schaffer JE, et al. Nat Chem Biol. 2017 Jul;13(7):737-744.

3. Scott TA, et al. ACS Chem Biol. 2019 Dec 20;14(12):2663-2671.

4. Batey SFD, et al. RSC Chem Biol. 2023;4(11):926-941.

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