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Chemical Structure : Obatoclax
CAS No.: 803712-79-0
Catalog No.: PC-42756Not For Human Use, Lab Use Only.
Obatoclax (GX15-070) mesylate is a potent inhibitor of Bcl-2 family with IC50s of 1-7 uM for Bcl-2, Bcl-XL, Bcl-w, Bcl-B, Mcl-1 and Bfl-1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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Obatoclax (GX15-070) mesylate is a potent inhibitor of Bcl-2 family with IC50s of 1-7 uM for Bcl-2, Bcl-XL, Bcl-w, Bcl-B, Mcl-1 and Bfl-1.
Obatoclax (GX15-070) potently interferes with the direct interaction between MCL-1 and BAK in intact mitochondrial outer membrane and inhibited the association between MCL-1 and BAK in intact cells;
| M.Wt | 413.49 | |
| Formula | C21H23N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 48.8 mg/mL |
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| Chemical Name/SMILES |
1H-Indole, 2-[2-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-, methanesulfonate (1:1) |
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1. Zhai D, et al. Cell Death Differ. 2006 Aug;13(8):1419-21.
2. Nguyen M, et al. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19512-7.
3. Konopleva M, et al. Cancer Res. 2008 May 1;68(9):3413-20.
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