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Obatoclax

Chemical Structure : Obatoclax

CAS No.: 803712-79-0

Obatoclax (Obatoclax Mesylate, GX15-070)

Catalog No.: PC-42756Not For Human Use, Lab Use Only.

Obatoclax (GX15-070) mesylate is a potent inhibitor of Bcl-2 family with IC50s of 1-7 uM for Bcl-2, Bcl-XL, Bcl-w, Bcl-B, Mcl-1 and Bfl-1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Obatoclax (GX15-070) mesylate is a potent inhibitor of Bcl-2 family with IC50s of 1-7 uM for Bcl-2, Bcl-XL, Bcl-w, Bcl-B, Mcl-1 and Bfl-1.
Obatoclax (GX15-070) potently interferes with the direct interaction between MCL-1 and BAK in intact mitochondrial outer membrane and inhibited the association between MCL-1 and BAK in intact cells;

Physicochemical Properties

M.Wt 413.49
Formula C21H23N3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 48.8 mg/mL

Chemical Name/SMILES

1H-Indole, 2-[2-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-, methanesulfonate (1:1)

References

1. Zhai D, et al. Cell Death Differ. 2006 Aug;13(8):1419-21.

2. Nguyen M, et al. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19512-7.

3. Konopleva M, et al. Cancer Res. 2008 May 1;68(9):3413-20.

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