Chemical Structure : Obrindatamab
CAS No.:
Obrindatamab
(Orlotamab, MGD009)
Catalog No.: PC-38833Not For Human Use, Lab Use Only.
Obrindatamab (Orlotamab, MGD009) is a Fc-bearing humanised bispecific dual-affinity re-targeting (DART) protein composed of Fv regions derived from monoclonal antibodies against the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Obrindatamab (Orlotamab, MGD009) is a Fc-bearing humanised bispecific dual-affinity re-targeting (DART) protein composed of Fv regions derived from monoclonal antibodies against the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities.
MGD009 DART protein targets and binds to the cell surface antigen B7-H3, at the same time, the anti-CD3 component binds to human CD3.
MGD009 (Orlotamab) cross-links the T cells to B7-H3-expressing tumor cells, activates and redirects endogenous T cells to kill B7-H3-expressing tumor cells, and inhibits proliferation of B7-H3-expressing tumor cells.
Isotype: IgG1 scFv-h-CH2-CH3(_scFv)_h-CH2-CH3.
Anti-[human CD276 (B7H3, B7-H3, B7RP-2)] and anti-[human CD3E (CD3 epsilon)], monoclonal antibody, bispecific.
Physicochemical Properties
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M.Wt
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Formula
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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