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Chemical Structure : Obrindatamab
Catalog No.: PC-38833Not For Human Use, Lab Use Only.
Obrindatamab (Orlotamab, MGD009) is a Fc-bearing humanised bispecific dual-affinity re-targeting (DART) protein composed of Fv regions derived from monoclonal antibodies against the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities.
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| 1 mg | Get quote | ||
| 5 mg | Get quote | ||
| 10 mg | Get quote | ||
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Obrindatamab (Orlotamab, MGD009) is a Fc-bearing humanised bispecific dual-affinity re-targeting (DART) protein composed of Fv regions derived from monoclonal antibodies against the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities.
MGD009 DART protein targets and binds to the cell surface antigen B7-H3, at the same time, the anti-CD3 component binds to human CD3.
MGD009 (Orlotamab) cross-links the T cells to B7-H3-expressing tumor cells, activates and redirects endogenous T cells to kill B7-H3-expressing tumor cells, and inhibits proliferation of B7-H3-expressing tumor cells.
Isotype: IgG1 scFv-h-CH2-CH3(_scFv)_h-CH2-CH3.
Anti-[human CD276 (B7H3, B7-H3, B7RP-2)] and anti-[human CD3E (CD3 epsilon)], monoclonal antibody, bispecific.
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| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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