Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Cathepsin-Odanacatib
Odanacatib

Chemical Structure : Odanacatib

CAS No.: 603139-19-1

Odanacatib (MK-0822, MK0822)

Catalog No.: PC-42147Not For Human Use, Lab Use Only.

Odanacatib (MK-0822) is a potent, selective, reversible and orally active cathepsin K inhibitor with IC50 of 0.2 nM.

Packing Price Stock Quantity
5 mg $128 In stock
10 mg $188 In stock
25 mg $328 In stock
50 mg $528 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Odanacatib (MK-0822) is a potent, selective, reversible and orally active cathepsin K inhibitor with IC50 of 0.2 nM.
Odanacatib (MK-0822) displays >300-fold selectivity over cathepsin B, L, S, F, and V.
Odanacatib (MK-0822) demonstrates the potentiation for the treatment of osteoporosis and other skeletal disorders associated with excessive bone remodeling.

Physicochemical Properties

M.Wt 525.5588
Formula C25H27F4N3O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥25 mg/mL

Chemical Name/SMILES

Pentanamide, N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl]amino]-, (2S)-

References

1. Gauthier JY, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):923-8.

2. Kumar V, et al. Mol Pharm. 2009 Jul-Aug;6(4):1118-24.

3. Eisman JA, et al. J Bone Miner Res. 2011 Feb;26(2):242-51.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: