Oditrasertib (DNL788, SAR443820)

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Chemical Structure : Oditrasertib

CAS No.: 2252271-93-3

Catalog No.: PC-20063Not For Human Use, Lab Use Only.

Oditrasertib (DNL788, SAR443820) is a potent, selective, orally bioavailable, brain penetrant inhibitor RIPK1 inhibitor with IC50 of 3.16 nM in human PBMCs and 1.6 nM in induced pluripotent stem cell (iPSC)-derived microglia.

Packing	Price	Stock
5 mg	$78	In stock
10 mg	$118	In stock
25 mg	$198	In stock
50 mg	$328	In stock
100 mg		Get quote

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Oditrasertib (DNL788, SAR443820) is a potent, selective, orally bioavailable, brain penetrant inhibitor RIPK1 inhibitor with IC50 of 3.16 nM in human PBMCs and 1.6 nM in induced pluripotent stem cell (iPSC)-derived microglia.

Physicochemical Properties

M.Wt	295.29
Formula	C14H15F2N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3,3-difluoro-2,2-dimethylpropanoyl)-2,3,4,5- tetrahydropyrido[3,4-f][1,4]oxazepine-9-carbonitrile

References

1. Patent WO2018213632 A1.
2. Hincelin-Mery A, et al. Clin Transl Sci. 2024 Jan;17(1):e13690.

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