Olaparib (AZD2281, KU-0059436) |CAS:763113-22-0 Probechem Biochemicals

Chemical Structure : Olaparib

CAS No.: 763113-22-0

Olaparib (AZD2281, KU-0059436, KU0059436, AZD-2281)

Catalog No.: PC-42410Not For Human Use, Lab Use Only.

Olaparib (AZD2281, KU-0059436) is a potent, specific, and orally active PARP inhibitor with IC50 of 5 and 1 nM for PARP1 and PARP2, respectively.

Packing	Price	Stock
50 mg	$98	In stock
100 mg	$158	In stock
250 mg	$258	In stock
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Biological Activity

Olaparib (AZD2281, KU-0059436) is a potent, specific, and orally active PARP inhibitor with IC50 of 5 and 1 nM for PARP1 and PARP2, respectively.
Olaparib (AZD2281, KU-0059436) displays 300-fold selectivity over tankyrase (TNKS-1 IC50=1.5 uM).
Olaparib (AZD2281, KU-0059436) shows standalone activity against BRCA1-deficient breast cancer cell lines.
Olaparib (AZD2281, KU-0059436) regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin.

Physicochemical Properties

M.Wt	434.4628
Formula	C24H23FN4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: 29 mg/mL
Chemical Name/SMILES	1(2H)-Phthalazinone, 4-[[3-[[4-(cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-

References

1. Menear KA, et al. J Med Chem. 2008 Oct 23;51(20):6581-91.

2. Evers B, et al. Clin Cancer Res. 2008 Jun 15;14(12):3916-25.

3. Rottenberg S, et al. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17079-84.

4. Hay T, et al. Cancer Res. 2009 May 1;69(9):3850-5.

Olaparib (AZD2281, KU-0059436, KU0059436, AZD-2281)

Biological Activity

Physicochemical Properties

References

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