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Olcegepant

Chemical Structure : Olcegepant

CAS No.: 204697-65-4

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Olcegepant (BIBN-4096, BIBN-4096BS, BIBN4096BS, BIBN 4096BS)

Catalog No.: PC-42294Not For Human Use, Lab Use Only.

Olcegepant (BIBN-4096, BIBN4096BS) is the first small molecule selective calcitonin gene-related peptide (CGRP) receptor antagonist with Ki of 14.4 nM for hCGRP.

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5 mg $158 In stock
10 mg $228 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Olcegepant (BIBN-4096, BIBN4096BS) is the first small molecule selective calcitonin gene-related peptide (CGRP) receptor antagonist with Ki of 14.4 nM for hCGRP.
Olcegepant (BIBN4096BS) inhibits the effects of CGRP, released by stimulation of the trigeminal ganglion, on facial blood flow in marmoset monkeys (1-30mg/kg, i.v.).

Physicochemical Properties

M.Wt 869.6451
Formula C38H47Br2N9O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 50 mg/mL
Chemical Name/SMILES

Piperazine, 1-[3,5-dibromo-N-[[4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl)-1-piperidinyl]carbonyl]-D-tyrosyl-L-lysyl]-4-(4-pyridinyl)-

References

1. Doods H, et al. Br J Pharmacol. 2000 Feb;129(3):420-3.

2. Powell KJ, et al. Br J Pharmacol. 2000 Nov;131(5):875-84.

3. Edvinsson L, et al. Eur J Pharmacol. 2002 Jan 2;434(1-2):49-53.

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