Olcegepant hydrochloride |CAS:586368-06-1 Probechem Biochemicals

Chemical Structure : Olcegepant hydrochloride

CAS No.: 586368-06-1

Olcegepant hydrochloride (BIBN-4096 hydrochloride;BIBN-4096BS hydrochloride;BIBN4096BS hydrochloride;BIBN 4096BS hydrochloride)

Catalog No.: PC-42296Not For Human Use, Lab Use Only.

Olcegepant hydrochloride (BIBN4096BS) is the first small molecule selective calcitonin gene-related peptide (CGRP) receptor antagonist with Ki of 14.4 nM for hCGRP.

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Biological Activity

Olcegepant hydrochloride (BIBN4096BS) is the first small molecule selective calcitonin gene-related peptide (CGRP) receptor antagonist with Ki of 14.4 nM for hCGRP.

Olcegepant (BIBN4096BS) inhibits the effects of CGRP, released by stimulation of the trigeminal ganglion, on facial blood flow in marmoset monkeys (1-30mg/kg, i.v.).

Physicochemical Properties

M.Wt	906.11
Formula	C38H47Br2N9O5.HCl
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	H2O: ≥ 66.66 mg/mL
Chemical Name/SMILES	1-Piperidinecarboxamide, N-[(1R)-2-[[(1S)-5-amino-1-[[4-(4-pyridinyl)-1-piperazinyl]carbonyl]pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl)-, hydrochloride

References

1. Doods H, et al. Br J Pharmacol. 2000 Feb;129(3):420-3.

2. Powell KJ, et al. Br J Pharmacol. 2000 Nov;131(5):875-84.

3. Edvinsson L, et al. Eur J Pharmacol. 2002 Jan 2;434(1-2):49-53.

Olcegepant hydrochloride (BIBN-4096 hydrochloride;BIBN-4096BS hydrochloride;BIBN4096BS hydrochloride;BIBN 4096BS hydrochloride)

Biological Activity

Physicochemical Properties

References

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