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Olesoxime

Chemical Structure : Olesoxime

CAS No.: 22033-87-0

Olesoxime (TRO 19622, NSC21311)

Catalog No.: PC-62134Not For Human Use, Lab Use Only.

Olesoxime (TRO 19622) is a cholesterol-like compound that binds directly to two components of the mitochondrial permeability transition pore (mPTP): the voltage-dependent anion channel and TSPO (or PBR).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Olesoxime (TRO 19622) is a cholesterol-like compound that binds directly to two components of the mitochondrial permeability transition pore (mPTP): the voltage-dependent anion channel and TSPO (or PBR).
Olesoxime rescues motor neurons from axotomy-induced cell death in neonatal rats and promoted nerve regeneration following sciatic nerve crush in vivio.
Olesoxime significantly reduces established mechano-allodynia and mechano-hyperalgesia.

Physicochemical Properties

M.Wt 399.65
Formula C27H45NO
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Cholest-4-en-3-one oxime

References

1. Bordet T, et al. J Pharmacol Exp Ther. 2007 Aug;322(2):709-20.

2. Schaller S, et al. J Pharmacol Exp Ther. 2010 Jun;333(3):696-706.

3. Sunyach C, et al. Neuropharmacology. 2012 Jun;62(7):2346-52.

4. Gouarné C, et al. Br J Pharmacol. 2013 Apr;168(8):1975-88.

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