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Oliceridine

Chemical Structure : Oliceridine

CAS No.: 1401028-24-7

Oliceridine (Olinvo, TRV130, TRV-130)

Catalog No.: PC-61681Not For Human Use, Lab Use Only.

Oliceridine (Olinvo, TRV130) is a potent, selective, and G protein biased μ opioid receptor (MOR) agonist with pEC50 of 8.1.

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Biological Activity

Oliceridine (Olinvo, TRV130) is a potent, selective, and G protein biased μ opioid receptor (MOR) agonist with pEC50 of 8.1.
Oliceridine displays 178-fold selectivity over KOR and 355-fold selectivity over DOR.
Oliceridine elicits robust G protein signaling, with potency and efficacy similar to morphine in cell-based assays.
Oliceridine is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine in mice and rats.

Physicochemical Properties

M.Wt 386.55
Formula C22H30N2O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-N-((3-methoxythiophen-2-yl)methyl)-2-(9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl)ethanamine

References

1. Chen XT, et al. J Med Chem. 2013 Oct 24;56(20):8019-31.

2. DeWire SM, et al. J Pharmacol Exp Ther. 2013 Mar;344(3):708-17.

3. Schneider S, et al. Biochemistry. 2016 Nov 22;55(46):6456-6466.

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