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Chemical Structure : Oliceridine hydrochloride
Catalog No.: PC-61682Not For Human Use, Lab Use Only.
Oliceridine hydrochloride (Olinvo, TRV130) is a potent, selective, and G protein biased μ opioid receptor (MOR) agonist with pEC50 of 8.1.
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Oliceridine hydrochloride (Olinvo, TRV130) is a potent, selective, and G protein biased μ opioid receptor (MOR) agonist with pEC50 of 8.1.
Oliceridine displays 178-fold selectivity over KOR and 355-fold selectivity over DOR.
Oliceridine elicits robust G protein signaling, with potency and efficacy similar to morphine in cell-based assays.
Oliceridine is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine in mice and rats.
| M.Wt | 423.012 | |
| Formula | C22H31ClN2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chen XT, et al. J Med Chem. 2013 Oct 24;56(20):8019-31.
2. DeWire SM, et al. J Pharmacol Exp Ther. 2013 Mar;344(3):708-17.
3. Schneider S, et al. Biochemistry. 2016 Nov 22;55(46):6456-6466.
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