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Oligomycin A

Chemical Structure : Oligomycin A

CAS No.: 579-13-5

Oligomycin A

Catalog No.: PC-27205Not For Human Use, Lab Use Only.

Oligomycin A (MCH 32) is a macrolide antibiotic and mitochondrial complex V ATP synthase inhibitor, inhibits mitochondrial F0F1-ATPase inhibitor with Ki of 1 uM, inhibits mitochondrial respiratory chain and oxidative phosphorylation (OXPHOS), shows shows anti-fungal and anti-cancer activities.

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Biological Activity

Oligomycin A (MCH 32) is a macrolide antibiotic and mitochondrial complex V ATP synthase inhibitor, inhibits mitochondrial F0F1-ATPase inhibitor with Ki of 1 uM, inhibits mitochondrial respiratory chain and oxidative phosphorylation (OXPHOS), shows shows anti-fungal and anti-cancer activities.

Physicochemical Properties

M.Wt 791.08
Formula C45H74O11
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-22-Ethyl-7,11,14,15-tetrahydroxy-6'-((R)-2-hydroxypropyl)-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-2,26-dioxaspiro[bicyclo[23.3.1]nonacosa[4,18,20]triene-27,2'-pyran]-3,9,13-trione

References

1. Chang L, et al. Neurobiol Dis. 2024 Sep;199:106573.

2. Takeuchi N, et al. Mol Med Rep. 2023 Dec;28(6):229.

3. Mackieh R, et al. Antibiotics (Basel). 2023 Mar 24;12(4):650.

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