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Olodaterol

Chemical Structure : Olodaterol

CAS No.: 868049-49-4

Olodaterol (BI1744, BI-1744)

Catalog No.: PC-43903Not For Human Use, Lab Use Only.

Olodaterol (BI 1744) is a potent, selective long-acting β2 adrenoceptor agonist with EC50 of 1.4 nM for hβ2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Olodaterol (BI 1744) is a potent, selective long-acting β2 adrenoceptor agonist with EC50 of 1.4 nM for hβ2.
Olodaterol shows >250 fold selectivity over hβ1.
Olodaterol exerts a bronchodilatory efficacy over 24 h in dogs and guinea pigs in the absence of systemic pharmacodynamic effects.

Physicochemical Properties

M.Wt 386.4415
Formula C21H26N2O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

H2O: 6.2 mg/mL

Chemical Name/SMILES

2H-1,4-Benzoxazin-3(4H)-one, 6-hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-

References

1. Bouyssou T, et al. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1410-4.

2. Bouyssou T,J Pharmacol Exp Ther. 2010 Jul;334(1):53-62. et al.

3. Wex E, et al. Br J Pharmacol. 2015 Jul;172(14):3537-47.

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