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Olodaterol hydrochloride

Chemical Structure : Olodaterol hydrochloride

CAS No.: 869477-96-3

Olodaterol hydrochloride (BI1744 CL)

Catalog No.: PC-36084Not For Human Use, Lab Use Only.

Olodaterol hydrochloride (BI1744 CL) is a potent, selective long-acting β2 adrenoceptor agonist with EC50 of 1.4 nM for hβ2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Olodaterol hydrochloride (BI1744 CL) is a potent, selective long-acting β2 adrenoceptor agonist with EC50 of 1.4 nM for hβ2; shows >250 fold selectivity over hβ1; exerts a bronchodilatory efficacy over 24 h in dogs and guinea pigs in the absence of systemic pharmacodynamic effects.

COPD

Phase 3 Clinical

Physicochemical Properties

M.Wt 413.895
Formula C21H17ClFN3OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(4-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine hydrochloride

References

1. Bouyssou T, et al. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1410-4.

2. Bouyssou T, et al. J Pharmacol Exp Ther. 2010 Jul;334(1):53-62.

3. Wex E, et al. Br J Pharmacol. 2015 Jul;172(14):3537-47.

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