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Olokizumab

Chemical Structure : Olokizumab

CAS No.:

Olokizumab (CDP6038)

Catalog No.: PC-38886Not For Human Use, Lab Use Only.

Olokizumab is a humanized antibody targeting interleukin-6 (IL-6), binds to IL-6 at Site 3 and neutralizes biological activity through blocking hexamer formation on the gp130 signaling axis.

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    Biological Activity

    Olokizumab is a humanized antibody targeting interleukin-6 (IL-6), binds to IL-6 at Site 3 and neutralizes biological activity through blocking hexamer formation on the gp130 signaling axis.
    Olokizumab binds to human IL-6 with an affinity (KD) of 10 pM.
    Olokizumab selectively blocks the final assembly of the IL-6 signaling complex.
    Olokizumab shows potential for inflammatory disease e.g. rheumatoid arthritis, as well as current SARS-CoV-2 infection.

    Isotype: IgG4-kappa.
    Anti-[human IL6;interleukin 6 (interferon, beta 2);IFNB2;interleukin-6;BSF2;HGF;HSF;IL 6;CDF;BSF-2;IFN-beta-2;interferon beta-2;interleukin BSF-2;hybridoma growth factor;CTL differentiation factor;B-cell stimulatory factor 2], human monoclonal antibody.

    Physicochemical Properties

    M.Wt
    Formula
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    Chemical Name/SMILES

    References

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