Catalog No.: PC-28136Not For Human Use, Lab Use Only.
Olopatadine (AL-4943A, KW-4679) is an antiallergic/antihistaminic agent that inhibits mast cell mediator release and possesses histamine H1 receptor (H1R) antagonist activity with Ki of 31.6 nM, shows much lower affinities for H2 receptors and H3 receptors (Ki>50 uM).
Olopatadine (AL-4943A, KW-4679) is an antiallergic/antihistaminic agent that inhibits mast cell mediator release and possesses histamine H1 receptor (H1R) antagonist activity with Ki of 31.6 nM, shows much lower affinities for H2 receptors and H3 receptors (Ki>50 uM).
Olopatadine (AL-4943A, KW-4679) inhibits histamine release in a concentration-dependent fashion (IC50 = 559 uM) from human conjunctival mast cell preparations in vitro.
Olopatadine inhibits histamine-induced phosphoinositide turnover in human conjunctival epithelial cells (IC50 = 10 nM), exhibits apparent noncompetitive antagonist properties with an estimated dissociation constant (Kb) of 19.9 nM.
Olopatadine (AL-4943A, KW-4679) effectively inhibits antigen- and histamine-stimulated conjunctivitis in guinea pigs.
