Olumacostat glasaretil (DRM01) is a small molecule inhibitor of acetyl coenzyme A (CoA) carboxylase (ACC).
Olumacostat glasaretil (DRM01) inhibits de novo lipid synthesis in primary and transformed human sebocytes; reduces saturated and monounsaturated fatty acyl chains across lipid species, including di- and triacylglycerols, phospholipids, cholesteryl esters, and wax esters.
Olumacostat glasaretil (DRM01) significantly reduces hamster ear sebaceous gland size.
Olumacostat glasaretil (DRM01) a pro-drug of TOFA with enhance delivery in vivo.
