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Olutasidenib

Chemical Structure : Olutasidenib

CAS No.: 1887014-12-1

Olutasidenib (FT-2102, FT2102)

Catalog No.: PC-35975Not For Human Use, Lab Use Only.

Olutasidenib (FT-2102) is a potent, orally bioavailable, brain penetrant, and selective mIDH1 inhibitor with IC50 of 21.2 nM and 114 nM for IDH1 mutant R132H and R132C, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Olutasidenib (FT-2102) is a potent, orally bioavailable, brain penetrant, and selective mIDH1 inhibitor with IC50 of 21.2 nM and 114 nM for IDH1 mutant R132H and R132C, respectively.
FT-2102 has excellent ADME/PK properties and reduces 2-hydroxyglutarate levels in an mIDH1 xenograft tumor model.

Physicochemical Properties

M.Wt 354.794
Formula C18H15ClN4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-[[(1S)-1-(6-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino]-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile

References

1. Caravella JA, et al. J Med Chem. 2020 Feb 27;63(4):1612-1623.
2. Rizzo A, et al. Cancer Treat Res Commun. 2021;27:100356.

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