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Chemical Structure : Omapatrilat
CAS No.: 167305-00-2
Catalog No.: PC-45435Not For Human Use, Lab Use Only.
Omapatrilat (BMS-186716) is a potent, dual inhibitor of the metalloproteases ACE and NEP with Ki of 0.64 nM and 0.45 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Omapatrilat (BMS-186716) is a potent, dual inhibitor of the metalloproteases ACE and NEP with Ki of 0.64 nM and 0.45 nM, respectively.
Omapatrilat (BMS-186716) shows moderate activity against APP, and low activity against ECE1.
Omapatrilat (BMS-186716) causes significant inhibition of plasma ACE and increases plasma renin activity, reduces blood pressure in spontaneously hypertensive rats; orally active.
| M.Wt | 408.5349 | |
| Formula | C19H24N2O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
7H-Pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid, octahydro-4-[[(2S)-2-mercapto-1-oxo-3-phenylpropyl]amino]-5-oxo-, (4S,7S,10aS)- |
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1. Robl JA, et al. J Med Chem. 1997 May 23;40(11):1570-7.
2. Fryer RM, et al. Br J Pharmacol. 2008 Mar;153(5):947-55.
3. Burrell LM, et al. Am J Hypertens. 2000 Oct;13(10):1110-6.
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