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Ombitasvir

Chemical Structure : Ombitasvir

CAS No.: 1258226-87-7

Ombitasvir (ABT-267, ABT267)

Catalog No.: PC-21352Not For Human Use, Lab Use Only.

Ombitasvir (ABT-267) is a potent, selective pan-genotypic inhibitor of HCV NS5A with EC50 of 1.7-19.3 pM against GT1a, -1b, -2a, -2b, -3a, -4a, and -5a and 366 pM against GT6a.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Ombitasvir (ABT-267) is a potent, selective pan-genotypic inhibitor of HCV NS5A with EC50 of 1.7-19.3 pM against GT1a, -1b, -2a, -2b, -3a, -4a, and -5a and 366 pM against GT6a.
Ombitasvir (ABT-267) decreases HCV RNA up to 3.10 log10 IU/mL during 3-day monotherapy in treatment-naive HCV GT1-infected subjects.

Physicochemical Properties

M.Wt 894.13
Formula C50H67N7O8
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Methyl ((S)-1-((S)-2-((4-((2S,5S)-1-(4-(tert-butyl)phenyl)-5-(4-((S)-1-((methoxycarbonyl)-L-valyl)pyrrolidine-2-carboxamido)phenyl)pyrrolidin-2-yl)phenyl)carbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

References

1. DeGoey DA, et al. J Med Chem. 2014 Mar 13;57(5):2047-57.

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