Onfasprodil (MIJ821) | NMDA NR2B inhibitor

Chemical Structure : Onfasprodil

Onfasprodil (MIJ-821, MIJ821)

Catalog No.: PC-73433Not For Human Use, Lab Use Only.

Onfasprodil (MIJ-821, MIJ821) is a potent, selective negative allosteric modulator of NR2B N-Methyl D-Aspartate receptor receptor (NR2B NMDA receptor), with a potentially low rate of the psychotomimetic side effects.

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Biological Activity

Onfasprodil (MIJ-821, MIJ821) is a potent, selective negative allosteric modulator/ antagonist of NR2B N-Methyl D-Aspartate receptor receptor (NR2B NMDA receptor), with a potentially low rate of the psychotomimetic side effects.

Physicochemical Properties

M.Wt	358.413
Formula	C20H23FN2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-((S)-2-((3aR,5R,6aS)-5-(2-fluorophenoxy)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-1-hydroxyethyl)pyridin-3-ol

References

1. Jesse E Hanson, et al. Neuropsychopharmacology. 2024 Jan;49(1):51-66.

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Onfasprodil (MIJ-821, MIJ821)

Biological Activity

Physicochemical Properties

References

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