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Onfasprodil

Chemical Structure : Onfasprodil

CAS No.: 1892581-29-1

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Onfasprodil (MIJ-821, MIJ821)

Catalog No.: PC-73433Not For Human Use, Lab Use Only.

Onfasprodil (MIJ-821, MIJ821) is a potent, selective negative allosteric modulator of NR2B N-Methyl D-Aspartate receptor receptor (NR2B NMDA receptor), with a potentially low rate of the psychotomimetic side effects.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Onfasprodil (MIJ-821, MIJ821) is a potent, selective negative allosteric modulator/ antagonist of NR2B N-Methyl D-Aspartate receptor receptor  (NR2B NMDA receptor), with a potentially low rate of the psychotomimetic side effects.

    Physicochemical Properties

    M.Wt 358.413
    Formula C20H23FN2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-((S)-2-((3aR,5R,6aS)-5-(2-fluorophenoxy)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-1-hydroxyethyl)pyridin-3-ol

    References

    1. Jesse E Hanson, et al. Neuropsychopharmacology. 2024 Jan;49(1):51-66.

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