Chemical Structure : Opa1 inhibitor 0
CAS No.:
Opa1 inhibitor 0
(Opitor-0)
Catalog No.: PC-24926Not For Human Use, Lab Use Only.
Opa1 inhibitor 0 (Opitor-0) is a reversible, noncompetitive inhibitor of mitochondrial dynamin-related protein Optic Atrophy 1 (OPA1) with IC50 of 3.0 uM against GTPase activity, effectively induces mitochondrial fragmentation in both human and mouse cells.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Opa1 inhibitor 0 (Opitor-0) is a reversible, noncompetitive inhibitor of mitochondrial dynamin-related protein Optic Atrophy 1 (OPA1) with IC50 of 3.0 uM against GTPase activity, effectively induces mitochondrial fragmentation in both human and mouse cells.
Opitor-0 significantly more potent than MYLS22。
Opitor-0 enhances apoptotic mitochondrial cytochrome c release and restore breast cancer cell sensitivity to the Bcl-2 inhibitor ABT-737.
Opitor-0 reverts breast cancer cell resistance to Bcl-2 inhibition in MDA-MB-231 cells.
Physicochemical Properties
|
M.Wt
|
519.62
|
|
Formula
|
C30H25N5O2S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
N-(1-benzyl-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
|
References
1. Pellattiero A, et al. Sci Adv. 2025 Jul 4;11(27):eadx4562.
Contact Us
sales@probechem.com
