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Chemical Structure : Opaganib
CAS No.: 915385-81-8
Catalog No.: PC-60524Not For Human Use, Lab Use Only.
Opaganib (ABC-294640, ABC294640) is a selective, competitive and orally bioavailable sphingosine kinase-2 (SphK-2) inhibitor with IC50 of 60 uM, Ki of 9.8 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $268 | In stock | |
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Opaganib (ABC294640) is a selective, competitive and orally bioavailable sphingosine kinase-2 (SphK-2) inhibitor with IC50 of 60 uM, Ki of 9.8 uM.
Opaganib (ABC294640) shows no activity against SphK-1 with IC50 of >100 uM.
Opaganib (ABC294640) attenuates S1P formation in intact cells, suppresses the proliferation of a broad panel of tumor cell lines, and inhibits tumor cell migration concomitant with loss of microfilaments.
Opaganib (ABC294640) demonstrates antitumor activity in adenocarcinoma xenograft models.
| M.Wt | 380.916 | |
| Formula | C23H25ClN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide |
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1. French KJ, et al. J Pharmacol Exp Ther. 2010 Apr;333(1):129-39.
2. Maines LW, et al. Inflammopharmacology. 2010 Apr;18(2):73-85.
3. Beljanski V, et al. J Pharmacol Exp Ther. 2010 May;333(2):454-64.
4. Antoon JW, et al. Endocrinology. 2010 Nov;151(11):5124-35.
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