Catalog No.: PC-60524Not For Human Use, Lab Use Only.
Opaganib (ABC-294640, ABC294640) is a selective, competitive and orally bioavailable sphingosine kinase-2 (SphK-2) inhibitor with IC50 of 60 uM, Ki of 9.8 uM.
Opaganib (ABC294640) is a selective, competitive and orally bioavailable sphingosine kinase-2 (SphK-2) inhibitor with IC50 of 60 uM, Ki of 9.8 uM.
Opaganib (ABC294640) shows no activity against SphK-1 with IC50 of >100 uM.
Opaganib (ABC294640) attenuates S1P formation in intact cells, suppresses the proliferation of a broad panel of tumor cell lines, and inhibits tumor cell migration concomitant with loss of microfilaments.
Opaganib (ABC294640) demonstrates antitumor activity in adenocarcinoma xenograft models.
