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Opiranserin

Chemical Structure : Opiranserin

CAS No.: 1441000-45-8

Opiranserin (VVZ-149, VVZ-000149)

Catalog No.: PC-60526Not For Human Use, Lab Use Only.

Opiranserin (VVZ-149, VVZ-000149) is a potent, selective, mixed glycine GlyT2 transporter blocker (IC50= 0.86 uM), purine P2X3 receptor antagonist (IC50=0.87 uM) and serotonin 5-HT2A receptor antagonist (IC50=1.3 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Opiranserin (VVZ-149, VVZ-000149) is a potent, selective, mixed glycine GlyT2 transporter blocker (IC50= 0.86 uM), purine P2X3 receptor antagonist (IC50=0.87 uM) and serotonin 5-HT2A receptor antagonist (IC50=1.3 uM).
Opiranserin demonstrates analgesic efficacy for postoperative pain.

Physicochemical Properties

M.Wt 394.512
Formula C21H34N2O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzamide, 4-butoxy-N-[[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl]-3,5-dimethoxy-

References

1. Nedeljkovic SS, et al. BMJ Open. 2017 Feb 17;7(2):e011035.

2. Oh J, et al. J Clin Pharmacol. 2018 Jan;58(1):64-73.

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