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Orevandrodeg

Chemical Structure : Orevandrodeg

CAS No.: 2756845-16-4

Orevandrodeg (BMS-986460, BMS986460, CC-2043137, CC2043137)

Catalog No.: PC-26347Not For Human Use, Lab Use Only.

Orevandrodeg (BMS-986460, CC-2043137) is a ligand-directed degrader composed of an E3 ubiquitin ligase-binding moiety that is conjugated, via a linker, to a moiety that targets a prostate specific tumor-associated antigen (TAA), with potential antineoplastic activity, androgen receptor degradation inducer.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Orevandrodeg (BMS-986460, CC-2043137) is a ligand-directed degrader composed of an E3 ubiquitin ligase-binding moiety that is conjugated, via a linker, to a moiety that targets a prostate specific tumor-associated antigen (TAA), with potential antineoplastic activity, androgen receptor degradation inducer.

    Physicochemical Properties

    M.Wt 811.93
    Formula C39H48F3N9O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (2R,6S)-4-[2-[[trans-4-[3-[6-Cyano-5-(trifluoromethyl)-3-pyridinyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]cyclohexyl]oxy]ethyl]-N-[3-[[(3S)-2,6-dioxo-3-piperidinyl]amino]phenyl]-2,6-dimethyl-1-piperazineacetamide

    References

    1. Patent WO2021262810 A1.

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