Chemical Structure : Orevandrodeg
CAS No.:
2756845-16-4
Orevandrodeg
(BMS-986460, BMS986460, CC-2043137, CC2043137)
Catalog No.: PC-26347Not For Human Use, Lab Use Only.
Orevandrodeg (BMS-986460, CC-2043137) is a ligand-directed degrader composed of an E3 ubiquitin ligase-binding moiety that is conjugated, via a linker, to a moiety that targets a prostate specific tumor-associated antigen (TAA), with potential antineoplastic activity, androgen receptor degradation inducer.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Orevandrodeg (BMS-986460, CC-2043137) is a ligand-directed degrader composed of an E3 ubiquitin ligase-binding moiety that is conjugated, via a linker, to a moiety that targets a prostate specific tumor-associated antigen (TAA), with potential antineoplastic activity, androgen receptor degradation inducer.
Physicochemical Properties
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M.Wt
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811.93
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Formula
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C39H48F3N9O5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2R,6S)-4-[2-[[trans-4-[3-[6-Cyano-5-(trifluoromethyl)-3-pyridinyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]cyclohexyl]oxy]ethyl]-N-[3-[[(3S)-2,6-dioxo-3-piperidinyl]amino]phenyl]-2,6-dimethyl-1-piperazineacetamide
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References
1. Patent WO2021262810 A1.
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