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Org-9935

Chemical Structure : Org-9935

CAS No.: 129425-83-8

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Org-9935 (Org9935;Org 9935)

Catalog No.: PC-61338Not For Human Use, Lab Use Only.

Org-9935 (Org9935) is a potent, selective PDE3 inhibitor with IC50 of 50 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Org-9935 (Org9935) is a potent, selective PDE3 inhibitor with IC50 of 50 nM.
    Org-9935 augments glucose-induced insulin release by rat isolated islets with EC50 of 20 uM.
    Org-9935 inhibits oocyte maturation in the naturally selected dominant follicle in rhesus macaques.

    Physicochemical Properties

    M.Wt 304.364
    Formula C15H16N2O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-(5,6-Dimethoxybenzo[b]thien-2-yl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone

    References

    1. Dent G, et al. Br J Pharmacol. 1991 Jun;103(2):1339-46.

    2. Jensen JT, et al. Contraception. 2008 Apr;77(4):303-7.

    3. El-Metwally M, et al. Eur J Pharmacol. 1997 Apr 18;324(2-3):227-32.

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