Org 25543 |CAS:495076-64-7 Probechem Biochemicals

Chemical Structure : Org 25543

CAS No.: 495076-64-7

Catalog No.: PC-60445Not For Human Use, Lab Use Only.

Org 25543 is a potent, highly selective glycine transporter 1 (GlyT2) inhibitor with IC50 of 16 nM with negligible affinity for GlyT1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Org 25543 is a potent, highly selective glycine transporter 1 (GlyT2) inhibitor with IC50 of 16 nM with negligible affinity for GlyT1.

M.Wt	448.988
Formula	C24H33ClN2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N-[[1-(dimethylamino)cyclopentyl]methyl]-3,5-dimethoxy-4-(phenylmethoxy)-, monohydrochloride (9CI)

1. Morita K, et al. J Pharmacol Exp Ther. 2008 Aug;326(2):633-45.

2. Rousseau F, et al. J Neurosci. 2008 Sep 24;28(39):9755-68.

3. Romei C, et al. J Neurochem. 2011 Oct;119(1):50-63.

4. Mingorance-Le Meur A, et al. Br J Pharmacol. 2013 Nov;170(5):1053-63.