Org 25935 | GlyT1 inhibitor | Probechem Biochemicals

Chemical Structure : Org 25935

Org 25935 (Org25935;Org-25935;SCH 900435)

Catalog No.: PC-60444Not For Human Use, Lab Use Only.

Org 25935 (SCH 900435) is a potent, selective glycine transporter 1 (GlyT1) inhibitor with IC50 of 100 nM.

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Biological Activity

Org 25935 (SCH 900435) is a potent, selective glycine transporter 1 (GlyT1) inhibitor with IC50 of 100 nM.
Org 25935 (SCH 900435) shows negligible action on GlyT2.
Org 25935 (SCH 900435) produces a robust and dose-dependent decrease in EtOH consumption in rats, reduces compulsive relapse-like drinking without the development of tolerance.

Physicochemical Properties

M.Wt	339.427
Formula	C21H25NO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	cis-N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl methyl)amino methylcarboxylic acid

References

1. Molander A, et al. Alcohol Alcohol. 2007 Jan-Feb;42(1):11-8.

2. Morita K, et al. J Pharmacol Exp Ther. 2008 Aug;326(2):633-45.

3. Lidö HH, et al. Alcohol Clin Exp Res. 2009 Jul;33(7):1151-7.

4. Vengeliene V, et al. Biol Psychiatry. 2010 Oct 15;68(8):704-11.

Org 25935 (Org25935;Org-25935;SCH 900435)

Biological Activity

Physicochemical Properties

References

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