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Chemical Structure : Org 25935
Catalog No.: PC-60444Not For Human Use, Lab Use Only.
Org 25935 (SCH 900435) is a potent, selective glycine transporter 1 (GlyT1) inhibitor with IC50 of 100 nM.
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Org 25935 (SCH 900435) is a potent, selective glycine transporter 1 (GlyT1) inhibitor with IC50 of 100 nM.
Org 25935 (SCH 900435) shows negligible action on GlyT2.
Org 25935 (SCH 900435) produces a robust and dose-dependent decrease in EtOH consumption in rats, reduces compulsive relapse-like drinking without the development of tolerance.
| M.Wt | 339.427 | |
| Formula | C21H25NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Molander A, et al. Alcohol Alcohol. 2007 Jan-Feb;42(1):11-8.
2. Morita K, et al. J Pharmacol Exp Ther. 2008 Aug;326(2):633-45.
3. Lidö HH, et al. Alcohol Clin Exp Res. 2009 Jul;33(7):1151-7.
4. Vengeliene V, et al. Biol Psychiatry. 2010 Oct 15;68(8):704-11.
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