Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Org 26576
Catalog No.: PC-61723Not For Human Use, Lab Use Only.
Org 26576 (MK 8777.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Org 26576 (MK 8777; SCH 900777) is a potent AMPA receptor (AMPAR) positive allosteric modulator; potentiates rat hippocampal AMPA receptor responses in an exposure-dependant manner (0.1-10 mg/kg, i.v.); increases BDNF release and enhanced neuronal differentiation and survival, an antidepressant has been halted due to a failed Phase II trial for major depressive disorder.
| M.Wt | 204.23 | |
| Formula | C11H12N2O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Jordan GR, et al. Neuropharmacology. 2005 Aug;49(2):254-64.
2. Su XW, et al. Psychopharmacology (Berl). 2009 Oct;206(2):215-22.
3. Bursi R, et al. Psychopharmacology (Berl). 2011 Dec;218(4):713-24.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
