Org 26576 | AMPAR PAM | Probechem Biochemicals

Chemical Structure : Org 26576

CAS No.: 1026791-61-6

Org 26576 (MK 8777, SCH 900777)

Catalog No.: PC-61723Not For Human Use, Lab Use Only.

Org 26576 (MK 8777, SCH 900777) is a potent AMPA receptor (AMPAR) positive allosteric modulator EC50 of 8-16 uM in rat hippocampal primary cultured neurons.

Packing	Price	Stock
10 mg	$128	In stock
25 mg	$218	In stock
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

Org 26576 (MK 8777, SCH 900777) is a potent AMPA receptor (AMPAR) positive allosteric modulator EC50 of 8-16 uM in rat hippocampal primary cultured neurons.
Org 26576 (MK 8777, SCH 900777) potentiates rat hippocampal AMPA receptor responses in an exposure-dependant manner (0.1-10 mg/kg, i.v.).
Org 26576 (MK 8777, SCH 900777) increases BDNF release and enhanced neuronal differentiation and survival.
Org 26576 (MK 8777, SCH 900777) is an antidepressant has been halted due to a failed Phase II trial for major depressive disorder.

Physicochemical Properties

M.Wt	204.23
Formula	C11H12N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S)-3,4-Propano-2,3-dihydropyrido[3,2-f][1,4]oxazepine-5(4H)-one

References

1. Jordan GR, et al. Neuropharmacology. 2005 Aug;49(2):254-64.

2. Su XW, et al. Psychopharmacology (Berl). 2009 Oct;206(2):215-22.

3. Bursi R, et al. Psychopharmacology (Berl). 2011 Dec;218(4):713-24.

Org 26576 (MK 8777, SCH 900777)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.