Chemical Structure : Org 34167
CAS No.:
198968-25-1
Org 34167
(Org 34,167)
Catalog No.: PC-20860Not For Human Use, Lab Use Only.
Org 34167 is a broad-spectrum inhibitor of HCN channels with IC50 of 23.4, 8.2 and 9.2 uM for HCN1, HCN2 and HCN4 channels, respectively, slowing activation and causing a hyperpolarising shift in voltage-dependence of activation.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Org 34167 is a broad-spectrum inhibitor of HCN channels with IC50 of 23.4, 8.2 and 9.2 uM for HCN1, HCN2 and HCN4 channels, respectively, slowing activation and causing a hyperpolarising shift in voltage-dependence of activation.
Org 34,167 (30 µM) significantly reduced I h-mediated sag in layer V mPFC pyramidal neurons in female BALB/c mice.
Org 34167 (0.5 mg/kg) reduced marble burying and increased the time spent mobile in the Porsolt swim and tail suspension tests in both male and female BALB/c mice.
Org 34,167 is effective at reducing depressive behaviours in mouse behavioural assays.
Physicochemical Properties
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M.Wt
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264.33
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Formula
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C17H16N2O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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C=CC[C@@H](C1=CC=CC=C1C2=NOC3=CC=CC=C23)N
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References
1. Paulo Pinares-Garcia, et al. Front Pharmacol. 2023 May 10;14:1159527.
2. Samotaeva IS, et al. Neuroscience. 2013 Jan 29;230:50-5.
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