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Org 42599

Chemical Structure : Org 42599

CAS No.: 501444-89-9

Org 42599 (Org42599)

Catalog No.: PC-62038Not For Human Use, Lab Use Only.

Org 42599 is a cell-permeant, allosterically binding, small-molecule agonist of luteinizing hormone (LH) receptor that rescues the folding and cell surface expression mutant mutant human LH receptors A593P and S616Y (EC50=70.8 nM).

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    Biological Activity

    Org 42599 is a cell-permeant, allosterically binding, small-molecule agonist of luteinizing hormone (LH) receptor that rescues the folding and cell surface expression mutant mutant human LH receptors A593P and S616Y (EC50=70.8 nM).

    Physicochemical Properties

    M.Wt 628.686
    Formula C26H31F3N6O5S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    5-amino-N-(tert-butyl)-2-(methylthio)-4-(3-(2-morpholinoacetamido)phenyl)thieno[2,3-d]pyrimidine-6-carboxamide 2,2,2-trifluoroacetate

    References

    1. Newton CL, et al. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7172-6.

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