Chemical Structure : Org43553
CAS No.: 501444-88-8
Catalog No.: PC-26422Not For Human Use, Lab Use Only.
Org 43553 (Org43553) is a selective allosteric agonist of luteinizing hormone-choriogonadotropin receptor (LHCGR, LHR) with EC50 of 4.7 nM.
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Org 43553 (Org43553) is a selective allosteric agonist of luteinizing hormone-choriogonadotropin receptor (LHCGR, LHR) with EC50 of 4.7 nM.
Org 43553 interacts with the endodomain of the LHR, whereas LH acts via the N-terminal exodomain.
Org 43553 inhibits luteinizing hormone (LH)-induced phospholipase C (PLC) with IC50 of 10 nM.
| M.Wt | 514.66 | |
| Formula | C24H30N6O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-Amino-N-(tert-butyl)-2-(methylthio)-4-(3-(2-morpholinoacetamido)phenyl)thieno[2,3-d]pyrimidine-6-carboxamide |
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1. Duan J, et al. Nature. 2021 Oct;598(7882):688-692.
2. van Koppen, C. J. et al. Naunyn Schmiedebergs Arch. Pharmacol. 378, 503–514 (2008).

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