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Org43553

Chemical Structure : Org43553

CAS No.: 501444-88-8

Org43553 (Org 43553, Org-43553)

Catalog No.: PC-26422Not For Human Use, Lab Use Only.

Org 43553 (Org43553) is a selective allosteric agonist of luteinizing hormone-choriogonadotropin receptor (LHCGR, LHR) with EC50 of 4.7 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Org 43553 (Org43553) is a selective allosteric agonist of luteinizing hormone-choriogonadotropin receptor (LHCGR, LHR) with EC50 of 4.7 nM.
Org 43553 interacts with the endodomain of the LHR, whereas LH acts via the N-terminal exodomain.
Org 43553 inhibits luteinizing hormone (LH)-induced phospholipase C (PLC) with IC50 of 10 nM.

Physicochemical Properties

M.Wt 514.66
Formula C24H30N6O3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-Amino-N-(tert-butyl)-2-(methylthio)-4-(3-(2-morpholinoacetamido)phenyl)thieno[2,3-d]pyrimidine-6-carboxamide

References

1. Duan J, et al. Nature. 2021 Oct;598(7882):688-692.

2. van Koppen, C. J. et al. Naunyn Schmiedebergs Arch. Pharmacol. 378, 503–514 (2008).

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