Chemical Structure : Orvepitant
CAS No.:
579475-18-6
Orvepitant
(GW-823296, GW823296)
Catalog No. : PC-61552Not For Human Use, Lab Use Only.
Orvepitant (GW823296) is a potent and selective, brain penetrant NK1 receptor antagonist with pKi of 10.2.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6155201
Biological Activity
Orvepitant (GW823296) is a potent and selective, brain penetrant NK1 receptor antagonist with pKi of 10.2.
Physicochemical Properties
M.Wt
628.623
Formula
C31H35F7N4O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(2R,4S)-N-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-4-[(8aS)-hexahydro-6-oxopyrrolo[1,2-a]pyrazin-2(1H)-yl]-N-methyl-1-piperidinecarboxamide
References
1. Di Fabio R, et al. Bioorg Med Chem
2. Ratti E, et al. J Psychopharmacol
3. Trower MK, et al. Exp Dermatol.
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