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Otamixaban

Chemical Structure : Otamixaban

CAS No.: 193153-04-7

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Otamixaban (FXV-673)

Catalog No.: PC-45940Not For Human Use, Lab Use Only.

A potent and selective factor Xa (FXa) inhibitor with Ki of 0.4 nM.

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100 mg $987.2 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A potent and selective factor Xa (FXa) inhibitor with Ki of 0.4 nM; shows >1,000-fold selectivity over thrombin, activated protein C (aPC), plasmin, and tissue-plasminogen activator (t-PA); dose-dependently prolongs the time to vessel occlusion and inhibits thrombus formation in canine models of thrombosis.

Thrombosis

Phase 3 Discontinued

Physicochemical Properties

M.Wt 446.4984
Formula C25H26N4O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzenepropanoic acid, 3-(aminoiminomethyl)-.alpha.-[(1R)-1-[[4-(1-oxido-4-pyridinyl)benzoyl]amino]ethyl]-, methyl ester, (.alpha.R)-

References

1. Guertin KR, et al. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1671-4.

2. Chu V, et al. Thromb Res. 2001 Aug 15;103(4):309-24.

3. Rebello SS, et al. J Cardiovasc Pharmacol. 2001 Aug;38(2):288-97.

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