Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-Cell Cycle/DNA Damage-ATM/ATR-Ovatodiolide
Ovatodiolide

Chemical Structure : Ovatodiolide

CAS No.: 3484-37-5

Ovatodiolide

Catalog No.: PC-28346Not For Human Use, Lab Use Only.

Ovatodiolide is a diterpenoid from a Chinese herb that possesses anticancer, anti-bacterial and anti-inflammatory properties, induces cell cycle G2/M arrest and apoptosis via a ROS-dependent ATM/ATR signaling in lung cancer cells.

Packing Price Stock Quantity
1 mg $138 In stock
5 mg $328 In stock
10 mg $258 In stock
25 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Ovatodiolide is a diterpenoid from a Chinese herb that possesses anticancer, anti-bacterial and anti-inflammatory properties, induces cell cycle G2/M arrest and apoptosis via a ROS-dependent ATM/ATR signaling in lung cancer cells.
Ovatodiolide induces cell cycle arrest and apoptosis in human oral squamous cell carcinoma Ca9-22 cells.
Ovatodiolide possesses bactericidal activity against H. pylori by reducing levels of ribosomal protein RpsB.
Ovatodiolide induces cell cycle G2/M arrest and apoptosis via a ROS-dependent ATM/ATR signaling pathways in lung cancer A549 and H1299 cells.
Ovatodiolide suppresses allergic airway inflammation and hyperresponsiveness in a murine model of asthma.
Ovatodiolide inhibits SARS-CoV-2 replication and ameliorates pulmonary fibrosis through suppression of the TGF-beta/TbetaRs signaling pathway.

Physicochemical Properties

M.Wt 328.41
Formula C20H24O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

O=C(O1)C([C@@](CC/C(C)=C/CCC2=C3)([H])[C@@]1([H])/C=C(C)/C[C@]3([H])OC2=O)=C

References

1. Arisawa M, et al. Planta Med. 1986 Aug;(4):297-9.

2. Hou YY, et al. Life Sci. 2009 Jul 3;85(1-2):26-32.

3. Lien HM, et al. Sci Rep. 2019 Mar 12;9(1):4205.

4. Yu CY, et al. Eur J Pharmacol. 2018 Jan 15;819:16-29.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: