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Chemical Structure : P1D-34
Catalog No.: PC-22075Not For Human Use, Lab Use Only.
P1D-34 is a first-in-class, potent and covalent PROTAC degrader of Pin1 with DC50 value of 177 nM in MV-4-11 cells, Dmax of 95%.
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P1D-34 is a first-in-class, potent and covalent PROTAC degrader of Pin1 with DC50 value of 177 nM in MV-4-11 cells, Dmax of 95%.
P1D-34 coupled the covalent Pin1 inhibitor Sulfopin to a cereblon ligand.
P1D-34 induces cell cycle arrest and apoptosis in AML cells, exhibits cell growth inhibitory activities with IC50 of 2-8 uM in a panel of AML cell lines: MV-4-11, MOLM-13, HL-60, THP-1, Kasumi-1, BDCM and OCI-AML3.
P1D-34 sensitizes ABT-199 against ABT-199-resistant AML cell lines, induces DNA damage and apoptosis by releasing ROS generation, and sensitizes 2-DG by down-regulating UPR pathways.
| M.Wt | 835.46 | |
| Formula | C40H59ClN6O9S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yunkai Shi, et al. Chem Sci. 2024 Feb 28;15(13):5027-5035.
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