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P62-mediated mitophagy inducer

Chemical Structure : P62-mediated mitophagy inducer

CAS No.: 1809031-84-2

P62-mediated mitophagy inducer (PMI)

Catalog No.: PC-62488Not For Human Use, Lab Use Only.

P62-mediated mitophagy inducer (PMI) is a small molecule P62-mediated mitophagy inducer that activates mitophagy without recruiting Parkin or collapsing membrane potential and retains activity in cells devoid of a fully functional PINK1/Parkin pathway.

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Biological Activity

P62-mediated mitophagy inducer (PMI) is a small molecule p62-mediated mitophagy inducer that activates mitophagy without recruiting Parkin or collapsing membrane potential and retains activity in cells devoid of a fully functional PINK1/Parkin pathway.
P62-mediated mitophagy inducer (PMI) induces doubling NQO1 activity at 1 uM, and upregulates Nrf2 and ARE-dependent antioxidant genes.
P62-mediated mitophagy inducer (PMI) increases the expression and signaling of the autophagic adaptor molecule P62/SQSTM1 and forces mitochondria into autophagy.
P62-mediated mitophagy inducer (PMI) disrupts the Nrf2-Keap1 interaction.

Physicochemical Properties

M.Wt 392.156
Formula C14H9IN4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(3-iodophenyl)-4-(3-nitrophenyl)-1H-1,2,3-triazole

References

1. East DA, et al. Chem Biol. 2014 Nov 20;21(11):1585-96.

2. Bertrand HC, et al. J Med Chem. 2015 Sep 24;58(18):7186-94.

3. Holmström KM, et al. Curr Opin Toxicol. 2016 Dec;1:80-91.

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