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Chemical Structure : P62-mediated mitophagy inducer
CAS No.: 1809031-84-2
Catalog No.: PC-62488Not For Human Use, Lab Use Only.
P62-mediated mitophagy inducer (PMI) is a small molecule P62-mediated mitophagy inducer that activates mitophagy without recruiting Parkin or collapsing membrane potential and retains activity in cells devoid of a fully functional PINK1/Parkin pathway.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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P62-mediated mitophagy inducer (PMI) is a small molecule p62-mediated mitophagy inducer that activates mitophagy without recruiting Parkin or collapsing membrane potential and retains activity in cells devoid of a fully functional PINK1/Parkin pathway.
P62-mediated mitophagy inducer (PMI) induces doubling NQO1 activity at 1 uM, and upregulates Nrf2 and ARE-dependent antioxidant genes.
P62-mediated mitophagy inducer (PMI) increases the expression and signaling of the autophagic adaptor molecule P62/SQSTM1 and forces mitochondria into autophagy.
P62-mediated mitophagy inducer (PMI) disrupts the Nrf2-Keap1 interaction.
| M.Wt | 392.156 | |
| Formula | C14H9IN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-(3-iodophenyl)-4-(3-nitrophenyl)-1H-1,2,3-triazole |
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1. East DA, et al. Chem Biol. 2014 Nov 20;21(11):1585-96.
2. Bertrand HC, et al. J Med Chem. 2015 Sep 24;58(18):7186-94.
3. Holmström KM, et al. Curr Opin Toxicol. 2016 Dec;1:80-91.
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